Toxicology, Anti-inflammatory and Anti-nociceptive study of recently launched Schwabe India product Rück-PainTM

Schwabe India has recently launched formulation Rück-PainTM. The product was launched for the spine and back related problem arising due to current lifestyle, environmental and genetic factors. Its anti-inflammatory, anti-nociceptive and toxicity effects of Rück-Pain™ in mice animal model was evaluated by a team of scientists from Amity University. For the study 6 groups of Swiss albino mice were selected for the vehicle control, disease control, treatment dose 1 (2.96ml/kg), treatment dose 2 (6ml/kg), treatment dose 3 (8.80ml/kg) and standard treatment. Sodium thioglycolate 0.1ml (1% solution) at neck joint region of mice was introduced for the spondylitis. By measuring erythrocyte sedimentation rate (ESR) anti-inflammatory effects was evaluated and area of inflammation was evaluated by Vernier calliper. Anti-nociceptive effect was evaluated using tail-flick assay. For the toxicology study histological changes in liver and spleen were assessed by treatment groups. Results of ESR in the groups of treatment doses 1, 2 and 3 were found 1.75 mm/h, 1. 62 mm/h and 1.50 mm/h respectively against 1.95 mm/h in disease control group and 1.55 in the standard treatment group. Area of inflammation in the groups of treatment doses 1, 2 and 3 were found to be reduced to 1.65 cm2, 1.57 cm2 and 1.53 cm2 respectively against 1.9 cm2 in disease control group and 1.55 cm2 in the standard treatment group. Nociceptive effect in the groups of treatment doses 1, 2 and 3 were found to be reduced to 9 seconds, 10 seconds and 10 seconds respectively against 7 seconds in disease control group and 10.5 seconds in the standard treatment group. Histological assessment showed there were no significantly observed cellular changes. From the study it was concluded that Ruck-Pain exhibits anti-inflammatory and nociceptive activities against spondylitis and was found non-toxic to treatment groups.

Reference: Bhardwaj R., Mittal A.K., Sharma N., Madan S., Kharkhwal H., Rajput S.K., Valavan R. Anti-inflammatory, Anti-nociceptive and Toxicity Studies of Homoeopathic Formulation Rück-Pain™. Advancements in Homeopathic Research. 2020, February 2020-April 2020 Vol. 5 No. 1.