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Anti-nociceptive Potential of Olmuv™ and its Safety Study through Skin Irritation Test – July – Dec 2020 & Jan – Dec 2021

Triumphant Conclusion: Mumbai-Based Motorist Team’s Unique Healing with Homeopathy Campaign

A motorist team led by a homeopathic doctor from Mumbai has successfully concluded the ground breaking “Heal with Homeopathy” campaign, which took place from July 23, 2022. The campaign covered a challenging route spanning Mumbai, Amritsar, Srinagar, Kargil, Ladakh, Leh, Chandigarh, and back to Mumbai, traversing some of the highest locations on their bikes. This pioneering campaign holds the distinction of being the world’s first homeopathy initiative conducted in such demanding circumstances, exploring breathtaking landscapes. The team expresses heartfelt gratitude for the overwhelming support and well wishes received, contributing to the resounding success of the campaign. The campaign’s social media posts were widely shared, spreading awareness about the power of homeopathy.

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Anti-nociceptive Potential of Olmuv™ and its Safety Study through Skin Irritation Test – July – Dec 2020 & Jan – Dec 2021

Anti-nociceptive Potential of Olmuv™ and its Safety Study through Skin Irritation Test 

Topical applications in the pain management play an important role. A formulation Olmuv™ developed with herbs used in homeopathy is targeted to treat pains of different origins. Though its ingredients are well-established traditionally as well as scientifically, there was no study conducted on this formulation. Hence this study was conducted with the objective to find out the anti-nociceptive effects and safety (skin irritation potential) of Olmuv TM . Materials and methods: Anti-nociceptive effect of Olmuv™ was conducted in Swiss albino mice. Animals were divided into 4 groups viz. vehicle control, disease control, standard therapy and treatment dose (6ml/kg). Pain was induced by the administration of carrageenan 0.1ml (1% solution) in paw joint region of animals. Eddy’s hot plate and tail flick method of hot water and cold-water assay were used to evaluate by the response time in seconds. Statistical analysis was accomplished using one-way analysis of variance (ANOVA) considering p value <=0.05 as significant. Skin irritation study was conducted by applying approximately 0.04 ml of test product on the marked test site using a brush in healthy human volunteers. This was un-occluded till it dried off, post which the test site was occluded. Filter papers dipped in 1% Sodium Lauryl Sulphate (SLS) solution and 0.9% Isotonic Saline Solution were filled in another well of patch test chambers and both were applied occlusively on the back of participants by Clinical Research Associates at Hour 0. Evaluation was done after 48 hours with scoring for erythema and oedema from 1 to 4. Results: Anti-nociceptive study displayed that the increased mean response time in the treatment groups in comparison to control groups. The Olmuv™ group mean response time was found to be 14, 8.5 and 9.8 seconds, while vehicle control group mean response time was found to be 9.2, 3.8 and 3.8 seconds in Eddy’s hot plate, hot tail-flick and cold tail-flick methods respectively after 7 hours. It was found almost similar with the standard treatment group in Eddy’s hot plate and cold tail-flick methods and closer with the same in hot tail-flick method. Skin irritation test showed that the score for erythema and oedema for Olmuv™ was found to be lower than the positive and negative controls. The mean score of Olmuv™, Isotonic Saline Solution and SLS solution were found to be 0.10, 0.07 and 3.06 respectively. Conclusion: Olmuv™ exhibited significant antinociceptive action in comparison with that of vehicle-treated and negative controls in all methods viz. Eddy’s hot plate, hot tail-flick and cold tail-flick. Furthermore, it is comparable with standard therapy in Eddy’s hot plate and closer with hot tail-flick and cold tail-flick methods. It was also found to be non-irritant in skin irritation study, i.e. found to be safe after usage on human skin. This novel formulation can be used effectively and safely to manage pain of different origins. Further studies are warranted to understand its molecular mechanism on pain receptors..

Reference: Bhardwaj, Rohit & Mittal, amit kumar & Sharma, Nitesh & Madan, Swati & Uk, Harsha Kharkwal & Rajput, Satyendra & Valavan, Ramachandran. (2021). Anti-nociceptive Potential of Olmuv™ and its Safety Study through Skin Irritation Test. 6. 18-23.

Journal of Evidence Based Homeopathy
Volume: 1, Issue: 1, January - June 2023