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Hepatoprotective effects of Lycopodium clavatum 30CH – Schwabe India

Hepatoprotective effects of Lycopodium clavatum 30CH in animals now scientifically established

It is known that Lycopodium clavatum is one of the most frequently used drugs for the digestive and liver complaints. To know its effectiveness on pracetamol or drug induced hepatitis, an experiment has been done on Wistar rat. Thirty rats have been subdivided in 6 groups. Animals receiving a dose of 3 g/kg of Pct (Pct is a drug with predictable toxicity, causing dose-dependent damage) on the 8th day were pretreated for 8 days with Lycopodium clavatum 30CH (0.25 ml/day) from the treated groups. A positive control group received similar treatment, replacing Lycopodium clavatum 30CH with 30% ethanol and a negative control received only 30% ethanol. The animals were sacrificed after 24 and 72 hours for tissue and blood sample collection.  Afterwards enzyme serum measurements indicative of liver damage and and liver histological and morphometric analyses were performed. Rats pretreated with Lycopodium clavatum 30CH shown significant reductions in ALT levels in the Lycopodium clavatum 30CH 24h-group compared to the respective control group, promoted a significant decrease in the number of acinar zone 1 affected by necrosis and inflammatory infiltration and inhibition of 1,2-glycol (glycogen) depletion in zone 3 (a significant reduction in Lycopodium clavatum 30CH 72 h group animals in comparison to the control group). Significant changes concerning the development of fibrosis or alterations in transaminase levels were not observed after 72 h. Hepatoprotective action of Lycopodium clavatum on acute Pct induced hepatitis has been shown.

Reference: Gustavo Henrique da Silva1, Pedro Paulo Barros, Gisele Mara Silva Gonc¸alves and Matheus Arnosti Landi, Hepatoprotective effect of Lycopodium clavatum 30CH on experimental model of paracetamol-induced liver damage in rats. Homoeopathy, January 2015Volume 104, Issue 1, Pages 29–35.

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