Crocus sativus in depression
Side effects of antidepressants pushed many researchers toward alternative psychopharmacology. Crocus sativus is used in homoeopathy for many psychological illnesses. It is increasingly popular in Indian medicine for the treatment of major depressive disorder (MDD). A meta-analysis was conducted to find effects of saffron supplementation on symptoms of depression among participants with MDD. For the analysis, electronic and non-electronic searches to identify all relevant randomized, double-blind controlled trials were done. The criteria for study selection included (1) adults (aged 18 and older) with symptoms of depression, (2) randomized controlled trial, (3) effects of saffron supplementation on depressive symptoms examined, and (4) study had either a placebo control or antidepressant comparison group. Using random effects modeling procedures, the researchers calculated weighted mean effect sizes separately for the saffron supplementation vs placebo control groups, and for the saffron supplementation vs antidepressant groups. The methodological quality of all studies was assessed using the Jadad score. The computer software Comprehensive Meta-analysis 2 was used to analyze the data.
Hausenblas HA, Saha D, Dubyak PJ, Anton SD, Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. J Integr Med. 2013 Nov;11(6):377-83. doi: 10.3736/j integrmed 2013056.
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