Syzygium jambolanum and Cephalandra indica are used in homoeopathy for treatment of type-2 diabetes. However, the molecular mechanisms responsible for such effects are not known. Authors of this study have used homoeopathic preparations of S. jambolanum and C. indica in mother tincture, 6c and 30c to examine the molecular mechanism of antidiabetic effects in the skeletal muscle of rats with high fat and fructose-induced type-2 diabetes mellitus. After 30 days treatment, fasting blood glucose, serum insulin and insulin signaling molecules in the skeletal muscle (gastrocnemius) were measured. Diabetic rats showed a significant decrease in serum insulin and lipid profile as well as low levels of insulin receptor (IR), v-akt murine thymoma viral oncogene homolog (Akt), p-Aktser473 and glucose transporter-4 (GLUT4) protein expression (p < 0.05) with a significant increase in fasting blood glucose level (p < 0.05) compared to the control group. Treatment with homoeopathic remedies significantly increased the serum insulin and expression of these proteins (p < 0.05) with a significant decrease in fasting blood glucose (p < 0.05) compared to diabetic rats.
The authors have concluded that in the present study homoeopathic preparations of S. jambolanum and C. indica, including ultramolecular dilutions exhibit antidiabetic effects, improving insulin action through activation of insulin signaling molecules in skeletal muscle of type-2 diabetic rats.
A quality control method of highly diluted and potentized homoeopathic remedies is important for curing patients applying homoeopathic therapy. Lenger detected photons in highly potentized homoeopathic remedies by delayed luminescence. The photons of Argentum metallicum 100MK and Cantharis 100MK magnetically bound to their carrier substances ethanol or saccharose were separated by their resonating magnetic field of about 2.06 MHz. The photons of these 100MK potency levels and of their reference substances were determined to be standard values calculated by the B 2-values of Bajpai's equation derived from the Hamiltonian equation. The stability of ethanolic Argentum metallicum 100MK and Cantharis 100MK declined to 1/3 of their photons within a month in contrast to saccharose globules with Argentum metallicum 100MK having been stable during the period of these investigations for almost 1 year. Some remedies delivered as CMK potency had been proved to be ethanol. The testing amount of high ethanolic potencies is limited to 40 μl because 80 μl resulted in an attenuation of the photons; 40 μl equal 16 medicated saccharose globules. Six unknown homoeopathic remedies could be identified as increasing potency levels of Argentum metallicum from 100MK to 1.000MK which indicates a calibration curve. The homoeopathic factories having sent the unknown remedies confirmed the measurements. A quality control of homoeopathic remedies is possible by comparing the different B 2-values of the remedies and their carrier substances.
Comments: The paper is of the interest to exhibit that medicines in sugar globules retain medicinal power for longer periods; and different potency levels in alcohol could be differentiated.
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