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Schwabe News Volume 5 | Issue 3-6 | March - June 2014

Holarrhena antidysenterica 1x


Introduction

Holarrhena antidysenterica belongs to the family Apocynaceae. It is an old Indian medicine, known by the common name “Kurchi”. The matured Kurchi bark contains about 4.5% alkaloids of which “Kurchicine” and “Conesimine” have been studied extensively.

A homoeopathic tincture is made from the dried bark. It is covered by Homoeopathic Pharmacopoeia of India.1 It was first proved by Dr. Mahendra Lal Sircar. Hahnemannian proving was conducted by CCRH and published in 2005. It has come to be known as a very powerful curative agent in cases of acute or chronic dysentery and fever. It is mainly useful as antiamoebicide. Apart from antidysenteric properties, the extract of this plant exerts its antihyperglycemic effect by retarding the carbohydrate absorption from intestine through the inhibition in α-glucosidase activity and therefore resists postprandial hyperglycemia.2

Many studies have established its therapeutic action in digestive disorders. Its stimulant and relaxant activities are mediated possibly through activation of histamine receptors and Ca (++) channel blockers, respectively. This study suggests its traditional use in other gastrointestinal disorders like constipation, colic and diarrhoea.3 A study conducted at the Institute of Post Graduate Ayurvedic Education and Research had found it efficacious to stop bleeding in bleeding piles.4 Studies on products containing Holarrhena antidysenterica have shown their usefulness in irritable bowel syndrome (IBS).5,6

Indications: Acute or chronic colitis, diarrhoea and dysentery. Useful in other symptoms like colic, bleeding per rectum, irritable bowel syndrome (IBS) and related problems.

Complementary medicines: Alpha-DP, Biocombination 08 and 09, Nux vomica 3x, Carbo vegetabilis 3x.

Dosage:  Unless otherwise prescribed, 1-2 tablets 2-3 times a day. Reduce the dose as symptoms improve. Appropriate diet regimen and oral rehydration salts are recommended to complement this therapy.  If complaints are not relieved, consult a specialist.

Side effects: Large doses may depress the blood pressure.

Contraindications and interactions:  No contra-indications and interactions with other drugs for the use of Schwabe’s Holarrhena antidysenterica 1x are known.

Presentation:  Bottle of 20gm.

References:
  • Homoeopathic Pharmacopoeia of India, Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy, Ministry of Health and Family Welfare, Government of India.
    Kazi Monjur Ali et al., Inhibitory effect of hydro-methanolic extract of seed of Holarrhenaantidysenterica on alpha-glucosidase activity and postprandial blood glucose level in normoglycemic rat, Journal of Ethnopharmacology, Volume 135, Issue 1, 26 April 2011, Pages 194–196
    Gilani AH et al., Pharmacological basis for the medicinal use of Holarrhena antidysenterica in gut motility disorders, Pharm Biol. 2010 Nov;48(11):1240-6.
    Pal A. et. al., A clinical study of kutaja (Holarrhena antidysenterica Wall) on shonitarsha, AYU 30, 4, 389—372
    Shrikant Tiwari et. al., Clinical Study on the Trial Drug New Diarex in Cases of Irritable Bowel Syndrome, Indian Journal of Clinical Practice (2001): (12), 7, 53-56
    Amit Lather et. al., Pharmacological Potential of Ayurvedic Formulation: Kutajghan Vati- A Review, J.Adv.Sci.Res, 2010, 1(2); 41-45