Lycopodium clavatum is a deep acting, predominantly anti-miasmatic remedy. It is a commonly used medicine for the gastric trouble, rheumatism, liver complaints, renal complaints, etc. Recent studies have shown that lycopodium has acetyl cholinesterase (AchE) inhibitory activity, which can be beneficial in cases of Dementia. However, no study has been conducted so far on animal models related to its memory and cerebral blood flow (CBF). Recently a study is done by Central Drug Research Institute, Lucknow on the effectiveness of homoeopathic Lycopodium on memory and cerebral blood flow in memory-impaired rats. Mother tincture (MT) and 200CH of Lycopodium were used to find its efficacy in memory. Whereas to test its effect on cerebral blood flow in memory- impaired rats the drug was used in MT, 30CH, 200CH and 1M. The study was done on intra-cerebro-ventricularly (ICV) administered streptozotocin (STZ) induced memory impairment in rats.
On the 1st and 3rd day memory deficit (streptozotocin 3mg/kg) was introduced by ICV. Male Sprague Dawley (SD) rats were treated with Lycopodium MT, 30CH, 200CH and 1M for 17 days. With the help of Morris maze test on the 14th, 15th and 16th day, learning and memory was assessed whereas cerebral blood flow judged by Laser Doppler flow meter on 17th day.
STZ (ICV) treated rats showed impairment in learning and memory along with reduced CBF. Lycopodium MT and 200 showed improvement in learning and memory. There was increased CBF in STZ (ICV) treated rats at all the potencies of Lyc studied.
The above study suggests that Lyc may be used as a drug of choice in condition of memory impairment due to its beneficial effect on CBF.
Reference: Kashif Hanif, Manoj Kumar, Neetu Singh, Rakesh Shukla. Effect of homeopathic Lycopodium clavatum on memory functions and cerebral blood flow in memory-impaired rats. Homeopathy, January 2015, Volume 104, Issue 1, Pages 24–28
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