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Schwabe News Volume 3 | Issue 2 | April 2012

Research news

Assessment of homeopathic medicine Aconitum napellus in the treatment of anxiety in an animal model

Aconitum napellus is a very frequently used homoeopathic medicine for many complaints associated with anxiety or fear. This study was conducted to scientifically assess the action of this drug in the treatment of generalized anxiety in an experimental model using rats.

In this study, 48 adult (two to three months old) male Wistar rats (Rattus rattus) were randomly divided in six groups (n= 8/treatment) and given the following treatments by gastric tube along 10 days: 1) control (diazepam 1 mg/kg/day); 2) negative control (0.15 mL saline solution/day); 3) ACH6 (0.15 mL Acon (6cH/day); 4) ACH12 (0.15 mL Acon 12cH/day); 5) ACH30 (0.15 mL Acon 30cH/day); and 6) ALC30 (0.15 mL 30% cereal alcohol/day). Behavioral effects were blindly and randomly assessed in elevated plus maze (EPM) and open field test.

The results showed that the drug in dilutions 12CH and 30CH exhibited possible anxiolytic effects on the central nervous system (CNS) since they increased the number of entries in the EPM open arms (12CH and 30CH) and the permanence time in the EPM open arms (30CH only). In the open field test the these preparations did not show effects on the locomotor system of rats. The authors have concluded that the dilutions 12CH and 30CH of Aconitum napellus exhibit anxiolytic effects on the CNS in an animal experimental model.

Caution: It is considered toxic at 1x and 2x levels.

Reference: Gabriele Baptista Haine, Samarah Hamidi El Ghandour, Sâmia Ahmad El Ghandour, Andersom Ricardo Fréz, Assessment of homeopathic medicine Aconitum napellus in the treatment of anxiety in an animal model, International Journal of High Dilution Research, Vol 11, No 38 (2012)



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